Born in 1931, the 3rd son of Louis and Marie Louise Gros, François was the student in the family. After receiving a diploma from the Dijon school of commerce, he worked in the family business along side his brothers and sister taking care of the accounting. Then Domaine Gros was divided.

In 1963, he married Danielle Knecht. He worked with his brother Jean until 1970. Then he decided to look after his own vines which consisted of 3 ha. He started from scratch by building his own winery in 1971 and at the same time created a small negociant business. In particular, the wines were sold to clients passing through the region thanks to a tasting cellar located on the RN74.

The wines were sold under the label François Gros as well as Gros père et fils. Then, in 1978, health problems required him to cut back on his activities. The domaine had to sell practically its entire production in barrels to a burgundian negociant. François' own negociant business ceased to exist. For 10 years, the activities of the domaine diminished.

In 1988, Anne started over, creating Domaine Anne and François Gros (François cared for the various vineyard parcels while Anne managed and worked at the domaine). In 1995, the domaine restructured taking the name domaine Anne Gros.